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Post-doc position (full salary and grant) available immediately (March 2025)
Project:
Malignant pleural mesothelioma is an aggressive cancer primarily induced by chronic inflammation and oxidative stress caused by inhaled asbestos fibers. Increasing evidence indicates that the immune tumor microenvironment is a key factor influencing the clinical outcomes of cancer patients. Single-cell transcriptomic analysis reveals that the tumor is infiltrated by immunosuppressive cells, including tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs). Clinical evidence further suggests that absolute eosinophil counts in peripheral blood inversely correlate with response to therapy and overall patient survival. Mechanistically, eosinophils secrete Charcot-Leyden Crystal protein, which interferes with therapeutic effectiveness. This project aims to characterize the roles of these immune cell types in oncogenesis and response to therapy.
Job description:
Candidates:
- should hold a PhD degree in molecular biology, biochemistry, medicine, veterinary medicine or equivalent.
- demonstrate knowledge in immunology
- have expertise in mouse models
Location:
Laboratory of molecular and cellular epigenetics, GIGA institute, University of Liège, Belgium
https://www.gigacme.uliege.be/cms/c_4222777/en/gigacme?id=c_4222777
Contract:
renewable one-year contract
available immediately
Application:
Motivation letter, CV and names of two referees should be sent to: luc.willems@uliege.be
